Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria-Reference-Cited by-同舟云学术

Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Published:2018-04 Issue:4 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Subramaniam Suvitha¹²,Schmid Christoph D.¹²³,Guan Xue Li⁴,Mäser Pascal¹²

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Swiss Institute of Bioinformatics, Basel, Switzerland

4. Nanyang Technological University, Singapore

Abstract

ABSTRACT Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01533-17

Reference33 articles.

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