Author:
Perkhofer Susanne,Striessnig Barbara,Sartori Bettina,Hausott Barbara,Ott Helmut W.,Lass-Flörl Cornelia
Abstract
ABSTRACTThe combination of platelets and anidulafungin at 0.03 μg/ml significantly (P< 0.05) reduced the germination rate and hyphal elongation inAspergillus fumigatuscompared to those with either anidulafungin only or an untreated control. Platelets decreased the expression of thefksgene, which plays an important role in cell wall synthesis. Our results suggest that human platelets plus anidulafungin might contribute to defense againstA. fumigatus.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
10 articles.
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