Interaction Between Acetohydroxamic Acid and 12 Antibiotics Against 14 Gram-Negative Pathogenic Bacteria-Reference-Cited by-同舟云学术

Interaction Between Acetohydroxamic Acid and 12 Antibiotics Against 14 Gram-Negative Pathogenic Bacteria

Published:1974-02 Issue:2 Volume:5 Page:106-110
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Musher Daniel M.¹²³,Saenz Corando¹²³,Griffith Donald P.¹²³

Affiliation:

1. Baylor College of Medicine, Houston, Texas 77025

2. Veterans Administration Hospital, Houston, Texas 77031

3. St. Luke's Episcopal Hospital: Houston, Texas 77025

Abstract

Acetohydroxamic acid (AHA) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. Because an antibacterial effect of AHA, and synergy between kanamycin and AHA have also been described, we studied the interaction between AHA and 12 antibiotics against 14 gram-negative bacteria. Synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in 5%. Infecting organisms would need to be studied individually before the antibacterial effect of AHA and an antibiotic could be predicted.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.5.2.106

Reference10 articles.

1. Urease inhibitors for hepatic coma: inhibition of "C-urea hydrolysis in mice by alkyl hydroxamates;Fishbein W. N.;Biochem. Med.,1970

2. Urease inhibitors for hepatic coma. II. Comparative efficacy of four lower hydroxamate homologs in vitro and in vivo;Fishbein W. N.;Proc. Soc. Exp. Biol. Med.,1970

3. Preparation and some properties of stable and carbon-14 and tritium-labeled short chain aliphatic hydroxamic acids;Fishbein W. N.;Anal. Biochem.,1969

4. Physiologic disposition of short chain aliphatic hydroxamates in the mouse. I. The one-through-four carbon hydroxamates; excretion and conversion to amides;Fishbein W. N.;J. Pharmacol. Exp. Ther.,1970

5. Urease activity and antibiotic sensitivity of bacteria;Gale G. R.;J. Bacteriol.,1966

Cited by 29 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. GC-MS Profiling of Reproductive Stage Withania somnifera for Antimicrobial and Anticancer Phytochemicals;Biomedical and Pharmacology Journal;2023-03-21

2. Prediction of Potential Natural Antibiotics based on Jamu Formula Using Machine Learning Approach;2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE);2022-11

3. Medical Dissolution and Prevention of Canine Struvite Urolithiasis;Veterinary Clinics of North America: Small Animal Practice;1999-01

4. Leading Article: Leading Article Anti-infectives: Prospects for improved therapy forHelicobacter pyloriinfection;Expert Opinion on Investigational Drugs;1996-08

5. Antibacterial action of the urease inhibitor acetohydroxamic acid on Helicobacter pylori.;Journal of Clinical Pathology;1993-04-01