Interaction Between Acetohydroxamic Acid and 12 Antibiotics Against 14 Gram-Negative Pathogenic Bacteria

Author:

Musher Daniel M.123,Saenz Corando123,Griffith Donald P.123

Affiliation:

1. Baylor College of Medicine, Houston, Texas 77025

2. Veterans Administration Hospital, Houston, Texas 77031

3. St. Luke's Episcopal Hospital: Houston, Texas 77025

Abstract

Acetohydroxamic acid (AHA) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. Because an antibacterial effect of AHA, and synergy between kanamycin and AHA have also been described, we studied the interaction between AHA and 12 antibiotics against 14 gram-negative bacteria. Synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in 5%. Infecting organisms would need to be studied individually before the antibacterial effect of AHA and an antibiotic could be predicted.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference10 articles.

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2. Urease inhibitors for hepatic coma. II. Comparative efficacy of four lower hydroxamate homologs in vitro and in vivo;Fishbein W. N.;Proc. Soc. Exp. Biol. Med.,1970

3. Preparation and some properties of stable and carbon-14 and tritium-labeled short chain aliphatic hydroxamic acids;Fishbein W. N.;Anal. Biochem.,1969

4. Physiologic disposition of short chain aliphatic hydroxamates in the mouse. I. The one-through-four carbon hydroxamates; excretion and conversion to amides;Fishbein W. N.;J. Pharmacol. Exp. Ther.,1970

5. Urease activity and antibiotic sensitivity of bacteria;Gale G. R.;J. Bacteriol.,1966

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