Author:
de Borba Luana,Villordo Sergio M.,Iglesias Nestor G.,Filomatori Claudia V.,Gebhard Leopoldo G.,Gamarnik Andrea V.
Abstract
The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified newcis-acting elements present in the capsid coding sequence that facilitate cyclization of the viral RNA by hybridization with a sequence involved in a local dumbbell structure at the viral 3′ untranslated region (UTR). The identified interaction differentially enhances viral replication in mosquito and mammalian cells.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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