Author:
de Borba Luana,Villordo Sergio M.,Iglesias Nestor G.,Filomatori Claudia V.,Gebhard Leopoldo G.,Gamarnik Andrea V.
Abstract
The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified newcis-acting elements present in the capsid coding sequence that facilitate cyclization of the viral RNA by hybridization with a sequence involved in a local dumbbell structure at the viral 3′ untranslated region (UTR). The identified interaction differentially enhances viral replication in mosquito and mammalian cells.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference46 articles.
1. Role of the dengue virus 5′ and 3′ untranslated regions in viral replication,2010
2. Flaviviridae: the viruses and their replication,2007
3. 5′- and 3′-noncoding regions in flavivirus RNA;Adv Virus Res,2003
4. Insights into dengue virus genome replication;Future Virol,2010
5. Functional RNA elements in the dengue virus genome;Viruses,2011
Cited by
72 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献