SETD6 Regulates E2-Dependent Human Papillomavirus Transcription-Reference-Cited by-同舟云学术

SETD6 Regulates E2-Dependent Human Papillomavirus Transcription

Published:2022-11-23 Issue:22 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jose Leny¹,Androphy Elliot J.¹²^ORCID,DeSmet Marsha¹

Affiliation:

1. Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA

2. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

Human papillomaviruses (HPV) cause cervical, anogenital, and oral cancers. Brd4 plays an important role in the HPV life cycle. SETD6 was recently shown to methylate Brd4. The current study demonstrates that methylation of Brd4 by SETD6 in HPV-episomal cells is required for the activation of viral transcription. This study illustrates a novel regulatory mechanism involving E2, Brd4, and SETD6 in the HPV life cycle and provides insight into the multiple roles of Brd4 in viral pathogenesis.

Funder

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01295-22

Reference49 articles.

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2. An acidic amphipathic helix in the Bovine Papillomavirus E2 protein is critical for DNA replication and interaction with the E1 protein

3. Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4