An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25-Reference-Cited by-同舟云学术

An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25

Published:2022-10-12 Issue:19 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Van Royen Tessa¹²^ORCID,Sedeyn Koen¹²,Moschonas George D.¹²,Toussaint Wendy³⁴,Vuylsteke Marnik⁵,Van Haver Delphi¹⁶⁷,Impens Francis¹⁶⁷,Eyckerman Sven¹⁷,Lemmens Irma¹⁷,Tavernier Jan¹⁷,Schepens Bert¹²,Saelens Xavier¹²^ORCID

Affiliation:

1. VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium

2. Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium

3. VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium

4. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium

5. Gnomixx, Melle, Belgium

6. VIB Proteomics Core, Ghent, Belgium

7. Department of Biomolecular Medicine, Ghent University, Ghent, Belgium

Abstract

Innate immune responses, including the production of type I and III interferons, play a crucial role in the first line of defense against RSV infection. However, only a poor induction of type I IFNs is observed during RSV infection, suggesting that RSV has evolved mechanisms to prevent type I IFN expression by the infected host cell.

Funder

Fonds Wetenschappelijk Onderzoek

Fonds De La Recherche Scientifique - FNRS

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01297-22

Reference71 articles.

1. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

2. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study