The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary T CM Cell Model of Latency-Reference-Cited by-同舟云学术

The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary T CM Cell Model of Latency

Published:2021-03-10 Issue:7 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sarabia Indra¹^ORCID,Huang Szu-Han²,Ward Adam R.¹²,Jones R. Brad¹²,Bosque Alberto¹^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC, USA

2. Infectious Disease Division, Weill Cornell Medical College, New York, New York, USA

Abstract

HIV-1 establishes a latent reservoir that persists under antiretroviral therapy. Antiretroviral therapy is able to stop the spread of the virus and the progression of the disease but does not target this latent reservoir.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01297-20

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1. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

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4. HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

5. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

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