Cell-Based Quantification of Chronic Wasting Disease Prions-Reference-Cited by-同舟云学术

Cell-Based Quantification of Chronic Wasting Disease Prions

Published:2010-08-15 Issue:16 Volume:84 Page:8322-8326
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bian Jifeng¹,Napier Dana¹,Khaychuck Vadim²,Angers Rachel²,Graham Catherine³,Telling Glenn¹²⁴

Affiliation:

1. Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, Kentucky 40536

2. Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky Medical Center, Lexington, Kentucky 40536

3. Canadian Food Inspection Agency, Lethbridge, Alberta T1J 3Z4, Canada

4. Department of Neurology, University of Kentucky Medical Center, Lexington, Kentucky 40536

Abstract

ABSTRACT Cell-based measurement of prion infectivity is currently restricted to experimental strains of mouse-adapted scrapie. Having isolated cell cultures with susceptibility to prions from diseased elk, we describe a modification of the scrapie cell assay allowing evaluation of prions causing chronic wasting disease, a naturally occurring transmissible spongiform encephalopathy. We compare this cervid prion cell assay to bioassays in transgenic mice, the only other existing method for quantification, and show this assay to be a relatively economical and expedient alternative that will likely facilitate studies of this important prion disease.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00633-10

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5. Cultured Cell Sublines Highly Susceptible to Prion Infection

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