In Vivo Induction of Apoptosis Correlating with Reduced Infectivity during Baculovirus Infection-Reference-Cited by-同舟云学术

In Vivo Induction of Apoptosis Correlating with Reduced Infectivity during Baculovirus Infection

Published:2003-02 Issue:3 Volume:77 Page:2227-2232
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Clarke Thomas E.¹,Clem Rollie J.¹

Affiliation:

1. Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506

Abstract

ABSTRACT Spodoptera frugiperda caterpillars were infected with a mutant of Autographa californica M nucleopolyhedrovirus lacking the antiapoptotic p35 gene. Viral infectivity, replication, and spread were substantially reduced compared to that of a control revertant virus. Terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling confirmed that apoptosis occurred in mutant-infected caterpillars, thus directly correlating reduced infectivity and in vivo induction of apoptosis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.3.2227-2232.2003

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