Precise Regulation of Differential Transcriptions of Various Catabolic Genes by OdcR via a Single Nucleotide Mutation in the Promoter Ensures the Safety of Metabolic Flux-Reference-Cited by-同舟云学术

Precise Regulation of Differential Transcriptions of Various Catabolic Genes by OdcR via a Single Nucleotide Mutation in the Promoter Ensures the Safety of Metabolic Flux

Published:2022-09-22 Issue:18 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Chen Kai¹,Ke Zhuang¹,Wang Sicheng¹,Wang Shen¹,Yang Ke¹,Jia Weibin¹,Zhu Jianchun²,Jiang Jiandong¹^ORCID

Affiliation:

1. Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, Nanjing, China

2. Laboratory Centre of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing, China

Abstract

Prokaryotes use various mechanisms, including improvement of the activity of detoxification enzymes, to cope with toxic intermediates produced during catabolism. However, studies on how bacteria accurately regulate differential transcriptions of various catabolic genes via a single regulator to ensure metabolic safety are scarce.

Funder

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.01182-22

Reference71 articles.

1. Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation

2. Local and global regulation of transcription initiation in bacteria