Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration-Reference-Cited by-同舟云学术

Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration

Published:2006-06 Issue:6 Volume:50 Page:2237-2239
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Inatsu Sakiko¹,Ohsaki Ayumi²,Nagata Kumiko¹

Affiliation:

1. Department of Microbiology, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan

2. Division of Medical Chemistry, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Kanda Chiyoda-ku, Tokyo 101-0062, Japan

Abstract

ABSTRACT Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q 1 at low concentrations of 0.8 to 3.2 μg/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01118-05

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