Increased c-di-GMP Levels Lead to the Production of Alginates of High Molecular Mass in Azotobacter vinelandii-Reference-Cited by-同舟云学术

Increased c-di-GMP Levels Lead to the Production of Alginates of High Molecular Mass in Azotobacter vinelandii

Published:2020-11-19 Issue:24 Volume:202 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Ahumada-Manuel Carlos L.¹,Martínez-Ortiz Iliana C.¹,Hsueh Brian Y.²,Guzmán Josefina¹,Waters Christopher M.²,Zamorano-Sánchez David³,Espín Guadalupe¹,Núñez Cinthia¹^ORCID

Affiliation:

1. Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico

2. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA

3. Programa de Biología Sintética y Biología de Sistemas, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico

Abstract

c-di-GMP has been widely recognized for its essential role in the production of exopolysaccharides in bacteria, such as alginate produced by Pseudomonas and Azotobacter spp. This study reveals that the levels of c-di-GMP also affect the physical properties of alginate, favoring the production of high-molecular-mass alginates in response to lower OTRs. This finding opens up new alternatives for the design of tailor-made alginates for biotechnological applications.

Funder

Foundation for the National Institutes of Health

UNAM | Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00134-20

Reference57 articles.

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