Evaluation of a Topical Interferon Inducer in Experimental Influenza Infection in Volunteers

Author:

Douglas R. Gordon1,Betts Robert F.1,Simons Ruth L.1,Hogan Patricia W.1,Roth Frieda K.1

Affiliation:

1. Infectious Disease Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Abstract

The prophylactic and/or therapeutic effect of a low-molecular-weight interferon inducer, CP-20,961, was tested in a double-blind placebo controlled study of experimental influenza A/England/42/72 (H 3 N 2 ) infection in normal volunteers. Ten volunteers received CP-20,961 and 10 received placebo. Interferon was detected in nasal secretions of nine of the former and three of the latter group (P < 0.05). Seven in each group became ill, and severity of illness was not different. Also, quantitative virus shedding patterns and antibody response were not different between the two groups. The negative result may have been due to the relatively low quantities of interferon induced.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference10 articles.

1. Effect of induced interferon in experimental rhinovirus infections in volunteers;Douglas R. G.;Infect. Immun.,1974

2. The limited effect of nasal interferon induced by rhinovirus and a topical chemical inducer on the course of infection;Gatmaitan B. G.;J. Infect. Dis.,1973

3. Sensitivity of common respiratory viruses to an interferon inducer in human cells;Hill D. A.;Lancet,1969

4. Evaluation of an interferon inducer in viral respiratory disease;Hill D. A.;J. Am. Med. Assoc.,1972

5. Knight V. 1964. The use of volunteers in medical virology p. 1-26. In E. Barger and J. L. Melnick (ed.) Progress in medical virology vol. 6. S. Karger Basel.

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