Transcellular transactivation by the human immunodeficiency virus type 1 tat protein

Author:

Helland D E1,Welles J L1,Caputo A1,Haseltine W A1

Affiliation:

1. Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

Abstract

The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference18 articles.

1. Trans-activator gene of human T-lymphotropic virus type III (HTLV-III);Arya S. K.;Science,1985

2. Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector;Caputo A.;J. Acquired Immune Defic. Syndr.,1990

3. The trans-activator gene of the human T cell Iymphotropic virus type IlI is required for replication;Dayton A. I.;Cell,1986

4. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients;Ensoli B.;Nature (London),1990

5. A quantitative bioassay for HIV-1 based on trans-activation;Felber B. K.;Science,1988

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