Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure-Reference-Cited by-同舟云学术

Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure

Published:1991-08 Issue:8 Volume:57 Page:2420-2425
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

George S E¹,Kohan M J¹,Whitehouse D A¹,Creason J P¹,Kawanishi C Y¹,Sherwood R L¹,Claxton L D¹

Affiliation:

1. Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.

Abstract

When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.57.8.2420-2425.1991

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