An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses-Reference-Cited by-同舟云学术

An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses

Published:2016-04 Issue:7 Volume:90 Page:3280-3283
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Carpentier Kathryn S.¹²,Geballe Adam P.¹²

Affiliation:

1. Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, USA

2. Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

ABSTRACT To establish productive infections, viruses must counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate antiviral pathways. The opposing goals of host and viral factors lead to evolutionary arms races that can be illuminated by evolutionary and computational methods and tested in experimental models. Here we illustrate how this perspective has been contributing to our understanding of the interactions of the protein kinase R pathway with large DNA viruses.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01996-15

Reference34 articles.

1. Rules of Engagement: Molecular Insights from Host-Virus Arms Races

2. Evolutionary conflicts between viruses and restriction factors shape immunity

3. Double-Stranded RNA Is Detected by Immunofluorescence Analysis in RNA and DNA Virus Infections, Including Those by Negative-Stranded RNA Viruses