The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited-Reference-Cited by-同舟云学术

The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Fernández-García Leandro¹,Angulo Jenniffer¹,Ramos Hade¹,Barrera Aldo¹,Pino Karla¹,Vera-Otarola Jorge¹^ORCID,López-Lastra Marcelo¹^ORCID

Affiliation:

1. Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

Abstract

Dengue virus (DENV), the etiological agent of dengue, a febrile and hemorrhagic disease, infects millions of people per year in tropical and subtropical countries. When infecting cells, DENV induces stress conditions known to inhibit canonical protein synthesis.

Funder

MINEDUC | Comisión Nacional de Investigación Científica y Tecnológica

Instituto Milenio en Inmunología e Inmunoterapia

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01998-20

Reference56 articles.

1. The global distribution and burden of dengue

2. Control of Dengue Virus Translation and Replication