Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition-Reference-Cited by-同舟云学术

Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition

Published:2016-05 Issue:5 Volume:60 Page:3183-3186
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lahiri Sushmita D.¹,Alm Richard A.¹

Affiliation:

1. Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA

Abstract

ABSTRACT Ceftazidime-avibactam has activity against Pseudomonas aeruginosa and Enterobacteriaceae expressing numerous class A and class C β-lactamases, although the ability to inhibit many minor enzyme variants has not been established. Novel VEB class A β-lactamases were identified during characterization of surveillance isolates. The cloned novel VEB β-lactamases possessed an extended-spectrum β-lactamase phenotype and were inhibited by avibactam in a concentration-dependent manner. The residues that comprised the avibactam binding pocket were either identical or functionally conserved. These data demonstrate that avibactam can inhibit VEB β-lactamases.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00047-16

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