Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay-Reference-Cited by-同舟云学术

Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay

Published:2021-04-20 Issue:5 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Lee Darren Y. J.¹^ORCID,Ashcroft Melinda M.¹^ORCID,Chow Eric P. F.²³⁴^ORCID,Sait Michelle⁵,De Petra Vesna⁵,Tschaepe Marlene⁵,Lange Sigrid⁵,Taiaroa George¹,Bradshaw Catriona S.²³,Whiley David M.⁶,Fairley Christopher K.²³,Howden Benjamin P.⁵,Chen Marcus Y.²³,Pasricha Shivani¹^ORCID,Williamson Deborah A.¹⁵⁷^ORCID

Affiliation:

1. Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

2. Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia

3. Central Clinical School, Monash University, Melbourne, Victoria, Australia

4. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia

5. Microbiological Diagnostic Unit Public Health Laboratory, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

6. The University of Queensland Centre for Clinical Research (UQ-CCR), Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

7. Department of Microbiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia

Abstract

Resistance-guided therapy (RGT) for gonorrhoea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Aptima Combo 2 assay, the ResistancePlus GC assay demonstrated 94.8% sensitivity and 100.0% specificity for Neisseria gonorrhoeae detection.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00089-21

Reference14 articles.

1. Current and future antimicrobial treatment of gonorrhoea – the rapidly evolving Neisseria gonorrhoeae continues to challenge

2. Impact of Rapid Susceptibility Testing and Antibiotic Selection Strategy on the Emergence and Spread of Antibiotic Resistance in Gonorrhea

3. Further evidence to support the individualised treatment of gonorrhoea with ciprofloxacin