Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease-Reference-Cited by-同舟云学术

Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease

Published:2006-12 Issue:12 Volume:74 Page:7010-7013
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Skaleric Uros¹,Gaspirc Boris¹,McCartney-Francis Nancy²,Masera Andrej³,Wahl Sharon M.²

Affiliation:

1. Department of Oral Medicine & Periodontology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

2. Oral Infection & Immunity Branch, NIDCR, NIH, Bethesda, Maryland

3. Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Abstract

ABSTRACT Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia , a major periodontopathogen, highlighting dual roles for NO.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00071-06

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