Independence of Circadian Timing from Cell Division in Cyanobacteria

Abstract

ABSTRACT In the cyanobacterium Synechococcus elongatus , cell division is regulated by a circadian clock. Deletion of the circadian clock gene, kai C, abolishes rhythms of gene expression and cell division timing. Overexpression of the ftsZ gene halted cell division but not growth, causing cells to grow as filaments without dividing. The nondividing filamentous cells still exhibited robust circadian rhythms of gene expression. This result indicates that the circadian timing system is independent of rhythmic cell division and, together with other results, suggests that the cyanobacterial circadian system is stable and well sustained under a wide range of intracellular conditions.