Allelic Diversity and Recombination in Campylobacter jejuni-Reference-Cited by-同舟云学术

Allelic Diversity and Recombination in Campylobacter jejuni

Published:2001-04-15 Issue:8 Volume:183 Page:2553-2559
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Suerbaum Sebastian¹,Lohrengel Marc¹,Sonnevend Agnes¹,Ruberg Florian²,Kist Manfred²

Affiliation:

1. Institut für Hygiene und Mikrobiologie der Universität Würzburg, D-97080 Würzburg,1 and

2. Institut für Medizinische Mikrobiologie und Hygiene der Universität Freiburg, D-79104 Freiburg,2 Germany

Abstract

ABSTRACT The allelic diversity and population structure of Campylobacter jejuni were studied by multilocus nucleotide sequence analysis. Sequences from seven housekeeping genes were obtained from 32 C. jejuni isolates isolated from enteritis patients in Germany, Hungary, Thailand, and the United States. Also included was strain NCTC 11168, the complete genomic sequence of which has recently been published. For all loci analyzed, multiple strains carried identical alleles. The frequency of synonymous and nonsynonymous sequence polymorphisms was low. The number of unique alleles per locus ranged from 9 to 15. These alleles occurred in 31 different combinations (sequence types), so that all but two pairs of strains could be distinguished from each other. Sequences were analyzed for evidence of recombination by the homoplasy test and split decomposition. These analyses showed that intraspecific recombination is frequent in C. jejuni and has generated extensive diversity of allelic profiles from a small number of polymorphic nucleotides.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.183.8.2553-2559.2001

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