Terminal Deoxynucleotidyl Transferase Is Not Required for Antibody Response to Polysaccharide Vaccines against Streptococcus pneumoniae and Salmonella enterica Serovar Typhi-Reference-Cited by-同舟云学术

Terminal Deoxynucleotidyl Transferase Is Not Required for Antibody Response to Polysaccharide Vaccines against Streptococcus pneumoniae and Salmonella enterica Serovar Typhi

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Belde Vivek¹,Cravens Matthew P.¹,Gulandijany Dania¹,Walker Justin A.¹,Palomo-Caturla Isabel¹,Alugupalli Akhil S.¹,Sandilya Vijay K.¹,Mahmoud Tamer²,Bäumler Andreas J.³,Kearney John F.²,Alugupalli Kishore R.¹

Affiliation:

1. Department of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, USA

Abstract

B cell antigen receptor (BCR) diversity increases by several orders of magnitude due to the action of terminal deoxynucleotidyl transferase (TdT) during V(D)J recombination. Unlike adults, infants have limited BCR diversity, in part due to reduced expression of TdT.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00211-18

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