Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus-Reference-Cited by-同舟云学术

Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus

Published:2020-08-19 Issue:9 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wong Sarah Sze Wah¹,Daniel Irene²,Gangneux Jean-Pierre³^ORCID,Jayapal Jeya Maheshwari²,Guegan Hélène³,Dellière Sarah¹⁴,Lalitha Prajna⁵,Shende Rajashri⁶,Madan Taruna⁷,Bayry Jagadeesh⁸,Guijarro J. Iñaki⁹,Kuppamuthu Dharmalingam²,Aimanianda Vishukumar¹^ORCID

Affiliation:

1. Institut Pasteur, Molecular Mycology Unit, CNRS, UMR2000, Paris, France

2. Department of Proteomics and Ocular Microbiology, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India

3. University of Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en santé, environnement et travail)–UMR_S 1085, Rennes, France

4. Parasitology-Mycology Laboratory, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France

5. Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, Tamil Nadu, India

6. National Centre for Cell Sciences, University of Pune, Pune, Maharashtra, India

7. National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, Maharashtra, India

8. Institut National de la Santé et de la Recherche Médicale, Centre de Recherché des Cordeliers, Sorbonne Université, Université de Paris, Paris, France

9. Institut Pasteur, Biological NMR Technological Platform, CNRS UMR 3528, Paris, France

Abstract

Even though both cellular and humoral immunities contribute to host defense, the role played by humoral immunity against the airborne opportunistic fungal pathogen Aspergillus fumigatus has been underexplored. In this study, we aimed at deciphering the role of the complement system, the major humoral immune component, against A. fumigatus . Mass spectrometry analysis of the proteins extracted from A. fumigatus conidial (asexual spores and infective propagules) surfaces opsonized with human serum indicated that C3 is the major complement protein involved.

Funder

Indo-French Centre for the Promotion of Advanced Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00212-20

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