The LiaFSR Transcriptome Reveals an Interconnected Regulatory Network in Group A Streptococcus

Author:

Sanson Misu A.1,Vega Luis Alberto1,Shah Brittany1,Regmi Shrijana1,Cubria M. Belen1,Horstmann Nicola23,Shelburne Samuel A.23,Flores Anthony R.1ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Sciences Center at Houston, Houston, Texas, USA

2. Department of Infectious Diseases, MD Anderson Cancer Center, Houston, Texas, USA

3. Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA

Abstract

The mechanisms by which bacteria sense the host environment and alter gene expression are poorly understood. LiaFSR is a gene regulatory system unique to Gram-positive bacteria, including group A Streptococcus (GAS), and responds to cell envelope stress.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference50 articles.

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4. Invasive Group A Streptococcal Infections Among People Who Inject Drugs and People Experiencing Homelessness in the United States, 2010–2017

5. Vega LA, Malke H, McIver KS. 2016. Virulence-related transcriptional regulators of Streptococcus pyogenes. In Ferretti JJ, Stevens DL, Fischetti VA (ed), Streptococcus pyogenes: basic biology to clinical manifestations. University of Oklahoma Health Sciences Center, Oklahoma City, OK.

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