Affiliation:
1. Virus Laboratory, University of California, Berkeley, California 94720
Abstract
The sensitivity of
Escherichia coli
B/r to X-irradiation is correlated with the replication cycle of deoxyribonucleic acid (DNA). The sensitivity to X-irradiation in the wild type can be attributed to the presence of nuclear targets plus DNA repair mechanisms. The effects of nuclear targets are observed in the recombination-deficient (
rec
−) mutant B/r, but the sensitivity reflected by changes in the slope of killing curves is absent. A study of different growth conditions indicates that maximal resistance to X rays occurs toward the middle of the division cycle. Evidence is offered that branched chromosomes respond as one-hit targets to X-irradiation. The killing effects of heavy-ion bombardment on
E. coli
are due primarily to ionizing radiation.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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