Zika Virus Infection Induces Interleukin-1β-Mediated Inflammatory Responses by Macrophages in the Brain of an Adult Mouse Model-Reference-Cited by-同舟云学术

Zika Virus Infection Induces Interleukin-1β-Mediated Inflammatory Responses by Macrophages in the Brain of an Adult Mouse Model

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jeong Gi Uk¹²³^ORCID,Lee Sumin¹,Kim Do Yeon¹⁴,Lyu Jaemyun⁵,Yoon Gun Young¹,Kim Kyun-Do¹,Ku Keun Bon¹⁶,Ko Junsu⁵,Kwon Young-Chan¹⁴^ORCID

Affiliation:

1. Department of Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea

2. Division of Infectious Diseases, Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts, USA

3. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

4. Medical Chemistry and Pharmacology, University of Science and Technology, Daejeon, Republic of Korea

5. Arontier Co., Ltd., Seoul, Republic of Korea

6. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

Abstract

Zika virus (ZIKV) associated neurological impairments are an important global health problem. Our results suggest that ZIKV infection in the mouse brain can induce IL-1β-mediated inflammation and complement activation, thereby contributing to the development of neurological disorders.

Funder

National Research Foundation of Korea

Korea Research Institute of Chemical Technology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00556-23

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