Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants-Reference-Cited by-同舟云学术

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants

Published:2022-08-10 Issue:15 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Moyo-Gwete Thandeka¹²,Madzivhandila Mashudu¹²,Mkhize Nonhlanhla N.¹²,Kgagudi Prudence¹²,Ayres Frances¹²,Lambson Bronwen E.¹²,Manamela Nelia P.¹²,Richardson Simone I.¹²,Makhado Zanele¹²,van der Mescht Mieke A.³,de Beer Zelda⁴,de Villiers Talita Roma⁴,Burgers Wendy A.⁵⁶,Ntusi Ntobeko A. B.⁶⁷⁸,Rossouw Theresa³,Ueckermann Veronica⁹,Boswell Michael T.⁹,Moore Penny L.¹²⁵¹⁰^ORCID

Affiliation:

1. National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa

2. MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

3. Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa

4. Tshwane District Hospital, Pretoria, South Africa

5. Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa

6. Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa

7. Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

8. Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

9. Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa

10. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa

Abstract

The evolution of SARS-CoV-2 has resulted in variants of concern (VOCs) with distinct spike mutations conferring various immune escape profiles. These variable mutations also influence the cross-reactivity of the antibody response mounted by individuals infected with each of these variants.

Funder

Bill and Melinda Gates Foundation

Department of Science and Technology, Republic of South Africa

National Research Foundation

South African Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00558-22

Reference42 articles.