In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides

Author:

Bergsson Gudmundur1,Arnfinnsson Jóhann2,Steingrı́msson Ólafur3,Thormar Halldor1

Affiliation:

1. Institute of Biology, University of Iceland,1

2. Department of Anatomy, University of Iceland Medical School,2 and

3. Department of Microbiology, National University Hospital,3 Reykjavik, Iceland

Abstract

ABSTRACT The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference14 articles.

1. In Vitro Inactivation of Chlamydia trachomatis by Fatty Acids and Monoglycerides

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3. Bergsson G. J. Arnfinnsson Ó. Steingrı́msson and H. Thormar. Killing of gram-positive cocci by fatty acids and monoglycerides. APMIS in press.

4. Inactivation of enveloped viruses in human bodily fluids by purified lipids.;Isaacs C. E.;Ann. N. Y. Acad. Sci.,1994

5. Antimicrobial activity of lipids added to human milk, infant formula, and bovine milk.;Isaacs C. E.;Nutr. Biochem.,1995

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