Effective Combination Therapy for Invasive Pneumococcal Pneumonia with Ampicillin and Intravenous Immunoglobulins in a Mouse Model-Reference-Cited by-同舟云学术

Effective Combination Therapy for Invasive Pneumococcal Pneumonia with Ampicillin and Intravenous Immunoglobulins in a Mouse Model

Published:2001-01 Issue:1 Volume:45 Page:316-318
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

De Hennezel Laetitia¹,Ramisse Françoise¹,Binder Patrice²,Marchal Gilles³,Alonso Jean-Michel³

Affiliation:

1. Centre d'Etudes du Bouchet, 91710 Vert Le Petit,1

2. Direction Centrale du Service de Santé des Armées, 00459 Armées,2 and

3. Institut Pasteur, 75015 Paris,3 France

Abstract

ABSTRACT Intranasal immunotherapy for Streptococcus pneumoniae invasive pneumonia with polyvalent immunoglobulins (IVIG) was effective in mice against pneumonia but failed to prevent bacteremia. The combination of subcurative doses of IVIG and of ampicillin was fully protective. Such an approach, successfully applied in the preantibiotic era, offers new perspectives for modern therapies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.316-318.2001

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