Affiliation:
1. Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut
Abstract
ABSTRACT
BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of
Staphylococcus aureus
ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes,
gyrA, gyrB, grlA
, and
grlB
, were sequenced. The data suggest that DNA gyrase is the primary target for BMS-284756 in
S. aureus
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference7 articles.
1. Antibacterial Spectrum of a Novel Des-Fluoro(6) Quinolone, BMS-284756
2. Hartman-Neumann S. K. DenBleyker L. A. Pelosi L. E. Lawrence J. F. Barrett and T. J. Dougherty. Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6)-quinolone BMS-284756. Antimicrob. Agents Chemother in press.
3. In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone
4. Mechanisms and Frequency of Resistance to Premafloxacin in
Staphylococcus aureus
: Novel Mutations Suggest Novel Drug-Target Interactions
5. National Committee for Clinical Library Standards
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 4th ed. M7–A4.
National Committee for Clinical Laboratory Standards Wayne Pa.
1997
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献