Clinical Isolate of Vancomycin-Heterointermediate Staphylococcus aureus Susceptible to Methicillin and In Vitro Selection of a Vancomycin-Resistant Derivative-Reference-Cited by-同舟云学术

Clinical Isolate of Vancomycin-Heterointermediate Staphylococcus aureus Susceptible to Methicillin and In Vitro Selection of a Vancomycin-Resistant Derivative

Published:2001-01 Issue:1 Volume:45 Page:349-352
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bobin-Dubreux Sophie¹,Reverdy Marie-Elisabeth¹,Nervi Chantal¹,Rougier Martine¹,Bolmström Anne²,Vandenesch François¹,Etienne Jerome¹

Affiliation:

1. Laboratoire de Microbiologie, EA 1655, Hôpital Edouard Herriot, 69437 Lyon cedex 03, France,1 and

2. AB BIODISK, S-169 56 Solna, Sweden2

Abstract

ABSTRACT A Staphylococcus aureus strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of vancomycin led to rapid selection of a stable progeny homogeneously resistant to vancomycin. Electron micrographs of strain MER showed enhanced cell wall thickness and abnormal septations typically seen with methicillin-resistant S. aureus having intermediate susceptibility to vancomycin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.349-352.2001

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