Marked Potentiation of Activity of β-Lactams against Methicillin-Resistant Staphylococcus aureus by Corilagin-Reference-Cited by-同舟云学术

Marked Potentiation of Activity of β-Lactams against Methicillin-Resistant Staphylococcus aureus by Corilagin

Published:2001-11 Issue:11 Volume:45 Page:3198-3201
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shimizu Masato¹,Shiota Sumiko¹,Mizushima Tohru¹,Ito Hideyuki²,Hatano Tsutomu²,Yoshida Takashi²,Tsuchiya Tomofusa¹

Affiliation:

1. Department of Microbiology1 and

2. Department of Pharmacognosy,2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan

Abstract

ABSTRACT We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus . We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various β-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.11.3198-3201.2001

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