Inhibition of Herpes Simplex Virus Reactivation by Dipyridamole-Reference-Cited by-同舟云学术

Inhibition of Herpes Simplex Virus Reactivation by Dipyridamole

Published:2001-12 Issue:12 Volume:45 Page:3657-3659
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tenser Richard B.¹,Gaydos Andrew¹,Hay Kathleen A.¹

Affiliation:

1. Division of Neurology and Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033

Abstract

ABSTRACT Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinase-negative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivation-enhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.12.3657-3659.2001

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