In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae-Reference-Cited by-同舟云学术

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae

Published:1994-12 Issue:12 Volume:38 Page:2908-2909
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dhople A M¹,Ibanez M A¹,Dhople A A¹

Affiliation:

1. Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901-6988.

Abstract

In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.12.2908

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