Lambda Interferon Inhibits Hepatitis B and C Virus Replication-Reference-Cited by-同舟云学术

Lambda Interferon Inhibits Hepatitis B and C Virus Replication

Published:2005-03-15 Issue:6 Volume:79 Page:3851-3854
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Robek Michael D.¹,Boyd Bryan S.¹,Chisari Francis V.¹

Affiliation:

1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California

Abstract

ABSTRACT Lambda interferon (IFN-λ) induces an intracellular IFN-α/β-like antiviral response through a receptor complex distinct from the IFN-α/β receptor. We therefore determined the ability of IFN-λ to inhibit hepatitis B virus (HBV) and hepatitis C virus (HCV) replication. IFN-λ inhibits HBV replication in a differentiated murine hepatocyte cell line with kinetics and efficiency similar to IFN-α/β and does not require the expression of IFN-α/β or IFN-γ. Furthermore, IFN-λ blocked the replication of a subgenomic and a full-length genomic HCV replicon in human hepatocyte Huh7 cells. These results suggest the possibility that IFN-λ may be therapeutically useful in the treatment of chronic HBV or HCV infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.6.3851-3854.2005

Reference20 articles.

1. Blight, K. J., A. A. Kolykhalov, and C. M. Rice. 2000. Efficient initiation of HCV RNA replication in cell culture. Science290:1972-1974.

2. Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

3. Coccia, E. M., M. Severa, E. Giacomini, D. Monneron, M. E. Remoli, I. Julkunen, M. Cella, R. Lande, and G. Uze. 2004. Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur. J. Immunol.34:796-805.

4. Donnelly, R. P., F. Sheikh, S. V. Kotenko, and H. Dickensheets. 2004. The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J. Leukoc. Biol.76:314-321.

5. Farrell, P. J., R. J. Broeze, and P. Lengyel. 1979. Accumulation of an mRNA and protein in interferon-treated Ehrlich ascites tumour cells. Nature279:523-525.

Cited by 379 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes;Antiviral Research;2024-01

2. Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation;Journal of Interferon & Cytokine Research;2023-09-01

3. Enhanced soluble expression of active recombinant human interleukin-29 using champion pET SUMO system;Biotechnology Letters;2023-06-02

4. HBV Infection and Host Interactions: The Role in Viral Persistence and Oncogenesis;International Journal of Molecular Sciences;2023-04-21

5. Analysis of the interferon lambda 3 and 4 gene single nucleotide polymorphisms and vaccine response against COVID-19;ADV HUM BIOL;2023