Human Herpesvirus 1 UL24 Gene Encodes a Potential PD-(D/E)XK Endonuclease-Reference-Cited by-同舟云学术

Human Herpesvirus 1 UL24 Gene Encodes a Potential PD-(D/E)XK Endonuclease

Published:2006-03 Issue:5 Volume:80 Page:2575-2577
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kniżewski Łukasz¹,Kinch Lisa²,Grishin Nick V.²³,Rychlewski Leszek⁴,Ginalski Krzysztof¹

Affiliation:

1. Interdisciplinary Centre for Mathematical and Computational Modelling, Warsaw University, 02-106 Warsaw, Poland

2. Howard Hughes Medical Institute, University of Texas, Southwestern Medical Center, Dallas, Texas 75390

3. Department of Biochemistry, University of Texas, Southwestern Medical Center, Dallas, Texas 75390

4. BioInfoBank Institute, 60-744 Poznań, Poland

Abstract

ABSTRACT Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae , Betaherpesvirinae , and Gammaherpesvirinae , suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.5.2575-2577.2006

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