Parameters of the Attenuated Schistosome Vaccine Evaluated in the Olive Baboon-Reference-Cited by-同舟云学术

Parameters of the Attenuated Schistosome Vaccine Evaluated in the Olive Baboon

Published:2004-09 Issue:9 Volume:72 Page:5526-5529
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kariuki Thomas M.¹,Farah Idle O.¹,Yole Dorcas S.¹,Mwenda Jason M.¹,Van Dam Govert J.²,Deelder André M.²,Wilson R. Alan³,Coulson Patricia S.³

Affiliation:

1. Institute of Primate Research, Karen, Nairobi, Kenya

2. Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands

3. Department of Biology, University of York, York, United Kingdom

Abstract

ABSTRACT Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.9.5526-5529.2004

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