The P Domain of the P0 Protein of Plasmodium falciparum Protects against Challenge with Malaria Parasites-Reference-Cited by-同舟云学术

The P Domain of the P0 Protein of Plasmodium falciparum Protects against Challenge with Malaria Parasites

Published:2004-09 Issue:9 Volume:72 Page:5515-5521
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rajeshwari K.¹,Patel Kalpesh¹,Nambeesan Savithri¹,Mehta Monika¹,Sehgal Alfica¹,Chakraborty Tirtha¹,Sharma Shobhona¹

Affiliation:

1. Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India

Abstract

ABSTRACT Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum . Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.9.5515-5521.2004

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