Clinical and Pharmacological Considerations for Concomitant Administration of Posaconazole and Isavuconazole with Letermovir-Reference-Cited by-同舟云学术

Clinical and Pharmacological Considerations for Concomitant Administration of Posaconazole and Isavuconazole with Letermovir

Published:2021-05-18 Issue:6 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Terrier Jean¹²^ORCID,Zanella Marie-Céline³^ORCID,Masouridi-Levrat Stavroula⁴,Kronig Ilona³,Chalandon Yves⁴,Vernaz Nathalie⁵,Van Delden Christian³,Papanicolaou Genovefa⁶,Neofytos Dionysios³^ORCID

Affiliation:

1. Division of Clinical Pharmacology and Toxicology Service, Geneva University Hospitals, Geneva, Switzerland

2. Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland

3. Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland

4. Hematology Division, Oncology Department, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland

5. Medical Directorate, Finance Directorate, Geneva University Hospitals, University of Geneva, Geneva, Switzerland

6. Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Abstract

We sought in this case-control retrospective study to compare posaconazole and isavuconazole (PCZ and IVC, respectively) plasma trough concentration ( C trough ) levels in high-risk allogeneic hematopoietic cell transplant (HCT) recipients who received letermovir (LET) or not. PCZ/IVC C trough levels were not found to be significantly different between cases and controls, as they were 1.31 mg/liter (median) (interquartile range [IQR], 0.90) versus 1.36 mg/liter (IQR, 1.16) ( P = 0.31) and 3.20 mg/liter (IQR, 2.40) versus 2.35 mg/liter (IQR, 1.50) ( P = 0.17), respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00274-21

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