Pyronaridine-Artesunate (Pyramax) for Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam-Reference-Cited by-同舟云学术

Pyronaridine-Artesunate (Pyramax) for Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Manh Nguyen Duc¹,Thanh Nguyen Van¹,Quang Huynh Hong²,Van Nguyen Thi Thanh¹,San Nguyen Ngoc¹,Phong Nguyen Chinh¹,Birrell Geoffrey W.³,Edstein Michael D.³,Edgel Kimberly A.⁴,Martin Nicholas J.⁴,Chavchich Marina³^ORCID

Affiliation:

1. Vietnam People’s Army Military Institute of Preventive Medicine (MIPM), Hanoi, Vietnam

2. Vietnam Ministry of Health Institute of Malariology, Parasitology and Entomology, Quy Nhon (IMPE-QN), Vietnam

3. Australian Defence Force Malaria and Infectious Disease Institute (ADFMIDI), Brisbane, Australia

4. U.S. Naval Medical Research Unit TWO (NAMRU-2), Singapore

Abstract

The rise in Plasmodium falciparum resistance to dihydroartemisinin-piperaquine in Vietnam justifies the need to evaluate alternative artemisinin-based combination therapies. Between July 2018 and October 2019, a single-arm trial of pyronaridine-artesunate (Pyramax, PA) was conducted in Dak Nong province, Vietnam.

Funder

DOD | U.S. Navy

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00276-21

Reference40 articles.

1. K13 Propeller Mutations in Plasmodium falciparum Populations in Regions of Malaria Endemicity in Vietnam from 2009 to 2016

2. Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam

3. Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study