Apoptotic Cells, Including Macrophages, Are Prominent in Theiler's Virus-Induced Inflammatory, Demyelinating Lesions-Reference-Cited by-同舟云学术

Apoptotic Cells, Including Macrophages, Are Prominent in Theiler's Virus-Induced Inflammatory, Demyelinating Lesions

Published:2003-04 Issue:7 Volume:77 Page:4383-4388
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Schlitt Brian P.¹,Felrice Matthew¹,Jelachich Mary Lou¹,Lipton Howard L.¹²³

Affiliation:

1. Departments of Neurology

2. Microbiology-Immunology

3. Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston and Chicago, and Evanston Hospital, Evanston, Illinois 60201

Abstract

ABSTRACT Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes, and ∼17% remained unidentified. In situ hybridization revealed viral RNA in ∼1% of apoptotic cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.7.4383-4388.2003

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