Immunogenic Modification of Ligilactobacillus agilis by Specific Amino Acid Substitution of Flagellin-Reference-Cited by-同舟云学术

Immunogenic Modification of Ligilactobacillus agilis by Specific Amino Acid Substitution of Flagellin

Published:2022-10-26 Issue:20 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Kajikawa Akinobu¹^ORCID,Eguchi Naoto¹,Suzuki Shunya¹

Affiliation:

1. Department of Applied Biology and Chemistry, Tokyo University of Agriculture, Setagaya, Tokyo, Japan

Abstract

The interactions between gut microbes and immune cells play an important role in the health and disease of hosts. Ligilactobacillus agilis is a flagellated commensal bacterium found in the gut of mammals and birds. However, the flagellin proteins of L. agilis are immunologically attenuated and barely induce TLR5-dependent inflammation, unlike the flagellins of several pathogenic bacteria.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.01277-22

Reference43 articles.

1. Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy

2. A Deletion Variant Study of the Functional Role of the Salmonella Flagellin Hypervariable Domain Region in Motility

3. Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling

4. A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin

5. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

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