GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture-Reference-Cited by-同舟云学术

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bruggemans Anne¹^ORCID,Vansant Gerlinde¹,Balakrishnan Mini²,Mitchell Michael L.²,Cai Ruby²,Christ Frauke¹,Debyser Zeger¹^ORCID

Affiliation:

1. Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium

2. Gilead Sciences Inc., Foster City, California, USA

Abstract

The ability of HIV to integrate into the host genome and establish latent reservoirs is the main hurdle preventing an HIV cure. LEDGINs are small-molecule integrase inhibitors that target the binding pocket of LEDGF/p75, a cellular cofactor that substantially contributes to HIV integration site selection.

Funder

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02328-20

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