Duplicated Sequence Motif in the Long Terminal Repeat of Maedi-Visna Virus Extends Cell Tropism and Is Associated with Neurovirulence-Reference-Cited by-同舟云学术

Duplicated Sequence Motif in the Long Terminal Repeat of Maedi-Visna Virus Extends Cell Tropism and Is Associated with Neurovirulence

Published:2007-04-15 Issue:8 Volume:81 Page:4052-4057
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Óskarsson Thórdur¹,Hreggvidsdóttir Hulda S.¹,Agnarsdóttir Gudrún¹,Matthíasdóttir Sigrídur¹,Ogmundsdóttir Margrét H.¹,Jónsson Stefán R.¹,Georgsson Gudmundur¹,Ingvarsson Sigurdur¹,Andrésson Ólafur S.¹,Andrésdóttir Valgerdur¹

Affiliation:

1. Institute for Experimental Pathology, University of Iceland, Keldur v/Vesturlandsveg, Reykjavík, Iceland

Abstract

ABSTRACT Maedi-visna virus (MVV) is a lentivirus of sheep causing chronic inflammatory disease of the lungs (maedi) and the nervous system (visna). We have previously shown that a duplicated sequence in the long terminal repeat (LTR) of MVV is a determinant of cell tropism. Here, we demonstrate that deletion of a CAAAT sequence from either one of the repeats resulted in poor virus growth in sheep choroid plexus cells. A duplication in the LTR encompassing the CAAAT sequence was found in four neurological field cases that were sequenced, but no duplication was present in the LTRs from seven maedi cases; one maedi isolate was mixed. These results indicate that the duplication in the LTR is associated with neurovirulence.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02319-06

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