Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors
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Published:2008-09
Issue:9
Volume:52
Page:3433-3437
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ISSN:0066-4804
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Container-title:Antimicrobial Agents and Chemotherapy
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language:en
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Short-container-title:Antimicrob Agents Chemother
Author:
Paeshuyse Jan1, Vliegen Inge1, Coelmont Lotte1, Leyssen Pieter1, Tabarrini Oriana2, Herdewijn Piet1, Mittendorfer Harald3, Easmon Johnny3, Cecchetti Violetta2, Bartenschlager Ralf4, Puerstinger Gerhard3, Neyts Johan1
Affiliation:
1. Rega Institute for Medical Research, K.U. Leuven, 3000 Leuven, Belgium 2. Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Perugia, Italy 3. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria 4. Department of Molecular Virology, University of Heidelberg, 69120 Heidelberg, Germany
Abstract
ABSTRACT
We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) α,γ-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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