Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection-Reference-Cited by-同舟云学术

Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Seman Brittany G.¹,Moore Jessica L.¹,Scherer Allison K.¹,Blair Bailey A.¹²,Manandhar Sony¹,Jones Joshua M.¹,Wheeler Robert T.¹²^ORCID

Affiliation:

1. Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA

2. Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA

Abstract

Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis infections, which claim the lives of nearly one-half of those afflicted. It has long been believed that filaments drive tissue invasion and yeast mediates bloodstream dissemination, but observation of these activities during infection has been prevented by technical limitations.

Funder

HHS | National Institutes of Health

Burroughs Wellcome Fund

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00415-18

Reference80 articles.

1. Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis