Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library-Reference-Cited by-同舟云学术

Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nurkanto Arif¹²^ORCID,Imamura Riyo³,Rahmawati Yulia²,Prabandari Erwahyuni Endang⁴,Waluyo Danang⁴,Annoura Takeshi⁵,Yamamoto Kazuki⁶,Sekijima Masakazu⁶,Nishimura Yuki⁷,Okabe Takayoshi³,Shiba Tomoo⁸,Shibata Norio⁹,Kojima Hirotatsu³,Duffy James¹⁰,Nozaki Tomoyoshi²

Affiliation:

1. Research Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), Cibinong, Indonesia

2. Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

3. Drug Discovery Initiative (DDI), The University of Tokyo, Tokyo, Japan

4. Research Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, Indonesia

5. Department of Parasitology, National Institute of Infectious Diseases (NIID), Tokyo, Japan

6. Department of Computer Science, Tokyo Institute of Technology, Tokyo, Japan

7. Department of Biological Sciences, Graduate of School of Sciences, The University of Tokyo, Chiba, Japan

8. Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan

9. Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Nagoya, Japan

10. Medicines for Malaria Venture, International Center Cointrin, Geneva, Switzerland

Abstract

Malaria is a mosquito-borne fatal infectious disease that affects humans and is caused by Plasmodium parasites, primarily Plasmodium falciparum . Widespread drug resistance compels us to discover novel compounds and alternative drug discovery targets.

Funder

Global Health Innovative Technology Fund

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00420-22

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Recent Progress in the Development of New Antimalarial Drugs with Novel Targets

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