Meropenem plus Ceftaroline Is Active against Enterococcus faecalis in an <i>In Vitro</i> Pharmacodynamic Model Using Humanized Dosing Simulations-Reference-Cited by-同舟云学术

Meropenem plus Ceftaroline Is Active against Enterococcus faecalis in an In Vitro Pharmacodynamic Model Using Humanized Dosing Simulations

Published:2022-10-18 Issue:10 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cusumano Jaclyn A.¹,Daffinee Kathryn E.¹,Piehl Emily C.¹,García-Solache Mónica²,Desbonnet Charlene²,Rice Louis B.²^ORCID,LaPlante Kerry L.¹²³⁴^ORCID

Affiliation:

1. Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA

2. Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

3. College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA

4. Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Abstract

The standard of care for serious Enterococcus faecalis infections is ampicillin plus ceftriaxone. Ampicillin’s inconvenient dosing schedule, drug instability, allergy potential, along with ceftriaxone’s high risk for Clostridioides difficile infection and its promotion of vancomycin-resistant enterococci (VRE), led our team to explore alternative options.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00426-22

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