Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression-Reference-Cited by-同舟云学术

Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression

Published:2021-06-10 Issue:13 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gao Wenying¹,Li Guangquan²,Zhao Simin³,Wang Hong¹,Huan Chen¹,Zheng Baisong¹,Jiang Chunlai³,Zhang Wenyan¹^ORCID

Affiliation:

1. Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China

2. Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, China

3. College of Life Science of Jilin University, Changchun, China

Abstract

Ubiquitination plays an essential role in viral infection. Deubiquitinating enzymes (DUBs) reverse ubiquitination by cleaving ubiquitins from target proteins, thereby affecting viral infection.

Funder

Science and Technology Department of Jilin Province

Key Laboratory of Molecular Virology, Jiliin Province

Chinese Ministry of Science and Technology

MOE | Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00460-21